Peptide Encapsulated Nanoparticles for Brain Drug Delivery

BBB is acting as a highly selective membrane that separates the circulating blood from brain fluid [1]. This barrier is formed by endothelial cells which are connected to each other at “tight” junctions that create a complete seal between them. Consequently, only lipophilic molecules are able to cross the barrier. Hydrophilic substances, in contrast, are unable to cross the lipid walls unless associated with a specific transporter. Because of this, BBB prevents the treatment in a number of brain diseases by blocking the delivery of drugs [2] (Figure 1).